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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MCM4 All Species: 37.58
Human Site: Y820 Identified Species: 59.05
UniProt: P33991 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P33991 NP_005905.2 863 96558 Y820 G K T P A L K Y Q Q L F E D I
Chimpanzee Pan troglodytes XP_528129 863 96543 Y820 G K T P A L K Y Q Q L F E D I
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_535063 929 104136 Y886 G K T P A L K Y Q Q L F E D I
Cat Felis silvestris
Mouse Mus musculus P49717 862 96718 Y819 G K T P A L K Y Q Q L F E D I
Rat Rattus norvegicus NP_387500 862 96552 Y819 G K T P A L K Y Q Q L F E D I
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515513 863 97108 Y820 G K T P A L K Y Q Q L F E D I
Chicken Gallus gallus XP_424376 859 96866 Y816 G K T P T L K Y Q Q L F E D L
Frog Xenopus laevis P30664 863 97105 Y820 G K T P A L K Y Q Q L F E D L
Zebra Danio Brachydanio rerio NP_944595 750 84021 A711 S G R G M V S A Y P R Q L E S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q26454 866 96592 Y822 G K V L T V P Y Q K L F S D I
Honey Bee Apis mellifera XP_624670 636 71159 V597 A R S V L H E V M E Q Q T L S
Nematode Worm Caenorhab. elegans Q21902 759 84917 Q720 V S E H L I V Q D F V A R Q H
Sea Urchin Strong. purpuratus XP_801985 910 101460 Y867 G K V V M L K Y H Q L Y E E F
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P43299 716 80315 A677 T H V S Y A N A L N W I S R K
Baker's Yeast Sacchar. cerevisiae P30665 933 104985 F883 Q A S D S M S F N E L I K Q I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 N.A. 87.6 N.A. 94.9 95.1 N.A. 92.4 86.3 85.7 71.3 N.A. 60.1 42.1 28.1 63.3
Protein Similarity: 100 100 N.A. 90 N.A. 97 97.3 N.A. 96.1 93.1 92.9 78.7 N.A. 77.3 54.3 46.9 76.3
P-Site Identity: 100 100 N.A. 100 N.A. 100 100 N.A. 100 86.6 93.3 0 N.A. 53.3 0 0 53.3
P-Site Similarity: 100 100 N.A. 100 N.A. 100 100 N.A. 100 93.3 100 13.3 N.A. 66.6 26.6 13.3 66.6
Percent
Protein Identity: N.A. N.A. N.A. 28.9 42.6 N.A.
Protein Similarity: N.A. N.A. N.A. 46.5 62.3 N.A.
P-Site Identity: N.A. N.A. N.A. 0 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 0 53.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 7 0 0 47 7 0 14 0 0 0 7 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 7 0 0 0 0 7 0 0 0 0 60 0 % D
% Glu: 0 0 7 0 0 0 7 0 0 14 0 0 60 14 0 % E
% Phe: 0 0 0 0 0 0 0 7 0 7 0 60 0 0 7 % F
% Gly: 67 7 0 7 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 7 0 7 0 7 0 0 7 0 0 0 0 0 7 % H
% Ile: 0 0 0 0 0 7 0 0 0 0 0 14 0 0 54 % I
% Lys: 0 67 0 0 0 0 60 0 0 7 0 0 7 0 7 % K
% Leu: 0 0 0 7 14 60 0 0 7 0 74 0 7 7 14 % L
% Met: 0 0 0 0 14 7 0 0 7 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 7 0 7 7 0 0 0 0 0 % N
% Pro: 0 0 0 54 0 0 7 0 0 7 0 0 0 0 0 % P
% Gln: 7 0 0 0 0 0 0 7 60 60 7 14 0 14 0 % Q
% Arg: 0 7 7 0 0 0 0 0 0 0 7 0 7 7 0 % R
% Ser: 7 7 14 7 7 0 14 0 0 0 0 0 14 0 14 % S
% Thr: 7 0 54 0 14 0 0 0 0 0 0 0 7 0 0 % T
% Val: 7 0 20 14 0 14 7 7 0 0 7 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % W
% Tyr: 0 0 0 0 7 0 0 67 7 0 0 7 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _